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Sirt1：一种在骨骼代谢和骨质疏松症中具有潜在作用的日益引人关注的分子。

Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis.

机构信息

Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China.

Orthopedic Clinical Medical Research Center and Intelligent Orthopedic Industry Technology Center of Gansu Province, Lanzhou 730030, China.

出版信息

Biomolecules. 2024 Aug 8;14(8):970. doi: 10.3390/biom14080970.

DOI:10.3390/biom14080970
PMID:39199358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11352324/
Abstract

Osteoporosis (OP) is a common metabolic bone disease characterized by low bone mass, decreased bone mineral density, and degradation of bone tissue microarchitecture. However, our understanding of the mechanisms of bone remodeling and factors affecting bone mass remains incomplete. Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase that regulates a variety of cellular metabolisms, including inflammation, tumorigenesis, and bone metabolism. Recent studies have emphasized the important role of SIRT1 in bone homeostasis. This article reviews the role of SIRT1 in bone metabolism and OP and also discusses therapeutic strategies and future research directions for targeting SIRT1.

摘要

骨质疏松症（OP）是一种常见的代谢性骨病，其特征是骨量低、骨矿物质密度降低以及骨组织微结构退化。然而，我们对骨重塑机制和影响骨量的因素的理解仍不完整。Sirtuin1（SIRT1）是一种烟酰胺腺嘌呤二核苷酸依赖性去乙酰化酶，调节多种细胞代谢，包括炎症、肿瘤发生和骨代谢。最近的研究强调了 SIRT1 在骨稳态中的重要作用。本文综述了 SIRT1 在骨代谢和 OP 中的作用，并讨论了针对 SIRT1 的治疗策略和未来研究方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2820/11352324/b2a3ff47bfd1/biomolecules-14-00970-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2820/11352324/d10003c6df53/biomolecules-14-00970-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2820/11352324/1fd9dd6007b5/biomolecules-14-00970-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2820/11352324/b2a3ff47bfd1/biomolecules-14-00970-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2820/11352324/d10003c6df53/biomolecules-14-00970-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2820/11352324/1fd9dd6007b5/biomolecules-14-00970-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2820/11352324/b2a3ff47bfd1/biomolecules-14-00970-g003.jpg

相似文献

[1]
Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis.

Biomolecules. 2024-8-8

[2]
SIRT1, a promising regulator of bone homeostasis.

Life Sci. 2021-3-15

[3]
Reduced Sirtuin1 expression at the femoral neck in women who sustained an osteoporotic hip fracture.

Osteoporos Int. 2016-7

[4]
SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis.

PLoS One. 2017-9-22

[5]
Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis.

Aging Cell. 2021-2

[6]
Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?

Pharmacol Res. 2019-3-9

[7]
The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling.

Int J Biol Sci. 2021

[8]
The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice.

Endocrinology. 2014-9

[9]
MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor β/δ-dependent manner.

Biochem Biophys Res Commun. 2016-9-9

[10]
Sirtuin1 promotes osteogenic differentiation through downregulation of peroxisome proliferator-activated receptor γ in MC3T3-E1 cells.

Biochem Biophys Res Commun. 2016-9-9

引用本文的文献

[1]
Oxidative stress and inflammation: roles in osteoporosis.

Front Immunol. 2025-8-12

[2]
Nicotinamide phosphoribosyltransferase in NAD metabolism: physiological and pathophysiological implications.

Cell Death Discov. 2025-8-8

[3]
Cellular senescence-from solid organs to vascularized composite allotransplants.

Geroscience. 2025-7-28

[4]
Co-morbid mechanisms of intervertebral disc degeneration and osteoporosis: biomechanical coupling and molecular pathways synergistically driving degenerative lesions.

J Orthop Surg Res. 2025-7-14

[5]
New Perspectives on Postmenopausal Osteoporosis: Mechanisms and Potential Therapeutic Strategies of Sirtuins and Oxidative Stress.

Antioxidants (Basel). 2025-5-17

[6]
[Mechanism of sodium valproate in inhibiting ferroptosis of bone marrow mesenchymal stem cells via the adenosine monophosphate-activated protein kinase/Sirtuin 1 axis].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2025-2-15

[7]
Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD.

Front Endocrinol (Lausanne). 2025-1-29

本文引用的文献

[1]
Bone Loss in Diabetes Mellitus: Diaporosis.

Int J Mol Sci. 2024-7-2

[2]
Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease.

Bone Res. 2024-7-10

[3]
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis.

Cell Discov. 2024-7-2

[4]
gCTRP3 inhibits oophorectomy‑induced osteoporosis by activating the AMPK/SIRT1/Nrf2 signaling pathway in mice.

Mol Med Rep. 2024-8

[5]
Update on fracture risk assessment in osteoporosis.

Curr Opin Endocrinol Diabetes Obes. 2024-8-1

[6]
SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1.

Cell Mol Life Sci. 2024-5-3

[7]
Osteoporosis: Emerging targets on the classical signaling pathways of bone formation.

Eur J Pharmacol. 2024-6-15

[8]
Unveiling the interplay of AMPK/SIRT1/PGC-1α axis in brain health: Promising targets against aging and NDDs.

Ageing Res Rev. 2024-4

[9]
SIRT7: a novel molecular target for personalized cancer treatment?

Oncogene. 2024-3

[10]
Sirtuins: exploring next-gen therapeutics in the pathogenesis osteoporosis and associated diseases.

Immunopharmacol Immunotoxicol. 2024-6

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