Environmental Health Institute, Singapore .
Emerg Infect Dis. 2010 May;16(5):847-9. doi: 10.3201/eid1605.091006.
In Singapore, after a major outbreak of dengue in 2005, another outbreak occurred in 2007. Laboratory-based surveillance detected a switch from dengue virus serotype 1 (DENV-1) to DENV-2. Phylogenetic analysis showed a clade replacement within DENV-2 cosmopolitan genotype, which accompanied the predominant serotype switch, and cocirculation of multiple genotypes of DENV-3.
在新加坡,2005 年发生了一次登革热的大规模暴发后,2007 年又发生了一次暴发。基于实验室的监测发现,登革热病毒血清型 1(DENV-1)转变为 DENV-2。系统进化分析显示,在 DENV-2 世界性基因型内发生了分支替换,这伴随着主要血清型的转变,以及 DENV-3 的多个基因型的共同流行。