Department of Hematology, the Affiliated DrumTower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, PR China.
Leuk Res. 2010 Dec;34(12):1596-600. doi: 10.1016/j.leukres.2010.03.034. Epub 2010 Apr 20.
To date, case-control studies on the association between methylenetetrahydrofolate reductase (MTHFR) C677T and childhood acute lymphoblastic leukemia have provided either controversial or inconclusive results. To clarify the effect of MTHFR C677T on the risk of childhood acute lymphoblastic leukemia, a meta-analysis of all case-control observational studies was performed. Heterogeneity (I(2)=65%, P<0.0001) for C677T among the studies was extreme. The random effects (RE) model showed that the 677T allele was not associated with a decreased susceptibility risk of childhood acute lymphoblastic leukemia compared with the C allele [OR=0.96, 95% confidence interval (CI) (0.88-1.04), P=0.34]. The contrast of homozygotes, recessive model and dominant model produced the same pattern of results as the allele contrast. Although MTHFR C677T was associated with increased risks of colorectal cancer, leukemia, and gastric cancer, our pooled data suggest no evidence for a major role of MTHFR C677T in the carcinogenesis of childhood acute lymphoblastic leukemia.
迄今为止，有关亚甲基四氢叶酸还原酶（MTHFR）C677T 与儿童急性淋巴细胞白血病之间关联的病例对照研究提供的结果存在争议或不一致。为了阐明 MTHFR C677T 对儿童急性淋巴细胞白血病风险的影响，对所有病例对照观察性研究进行了荟萃分析。研究之间的 C677T 异质性（I（2）=65%，P<0.0001）非常极端。随机效应（RE）模型表明，与 C 等位基因相比，677T 等位基因与儿童急性淋巴细胞白血病的易感性降低风险无关[比值比（OR）=0.96，95%置信区间（CI）（0.88-1.04），P=0.34]。同型合子、隐性模型和显性模型的对比产生了与等位基因对比相同的结果模式。尽管 MTHFR C677T 与结直肠癌、白血病和胃癌的风险增加有关，但我们的汇总数据表明，MTHFR C677T 在儿童急性淋巴细胞白血病的发生发展中没有主要作用的证据。
