CGP 20376对沙鼠体内马来布鲁线虫及寄生虫抗原血症的影响
Effect of CGP 20376 on Brugia malayi and parasite antigenemia in jirds.
作者信息
Chandrashekar R, Subrahmanyam D, Weil G J
机构信息
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
出版信息
J Parasitol. 1991 Jun;77(3):479-82.
This study was designed to investigate the activity of CGP 20376, a benzothiazole derivative, against Brugia malayi in jirds and to illustrate the utility of parasite antigen detection as a means of monitoring drug efficacy in filariasis. Drug treatment was 100% effective in jirds treated 3 or 24 days after infection. Microfilaria and adult worm counts were reduced (relative to counts in sham-treated control animals) by 96% and 95%, respectively, in animals treated 153 days after infection. Four of 6 animals in this treatment group cleared their microfilaremias and were free of adult worms 5 mo after treatment. Thus, CGP 20376 was effective against all life cycle stages of B. malayi in jirds. Parasite antigen levels in jird sera were consistent with parasitological results in all treatment groups, but antigen clearance was incomplete in some cases after apparently successful treatment of mature and immature infections.
本研究旨在调查苯并噻唑衍生物CGP 20376对沙鼠体内马来布鲁线虫的活性，并阐明寄生虫抗原检测作为监测丝虫病药物疗效手段的实用性。在感染后3天或24天接受治疗的沙鼠中，药物治疗的有效率为100%。在感染后153天接受治疗的动物中，微丝蚴和成虫数量（相对于假治疗对照动物的数量）分别减少了96%和95%。该治疗组6只动物中有4只在治疗后5个月清除了微丝蚴血症且无成虫。因此，CGP 20376对沙鼠体内马来布鲁线虫的所有生命周期阶段均有效。沙鼠血清中的寄生虫抗原水平与所有治疗组的寄生虫学结果一致，但在成熟和未成熟感染的明显成功治疗后，某些情况下抗原清除并不完全。
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