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诊断微量白蛋白尿及其对 2 型糖尿病患者药物治疗的影响:初级保健中的欧洲调查。

Diagnosing microalbuminuria and consequences for the drug treatment of patients with type 2 diabetes: a European survey in primary care.

机构信息

Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway.

出版信息

Diabetes Res Clin Pract. 2010 Aug;89(2):103-9. doi: 10.1016/j.diabres.2010.03.023. Epub 2010 Apr 21.

Abstract

AIMS

To assess general practitioners (GPs) knowledge of guideline recommendations on diagnosing microalbuminuria (MA) and to evaluate how this diagnosis influences drug treatment of diabetes patients.

METHODS

A postal case-history based questionnaire describing a male patient (previously not tested for MA) with type 2 diabetes who had several risk markers for cardiovascular disease.

RESULTS

2078GPs from nine European countries were included, with response rates varying from 7% to 43%. Almost all GPs recommended annual testing for MA. Forty-five to 77% (depending on country) of GPs required more than one positive test to diagnose MA. The absolute increase in the percentages of GPs who would supplement the patient's drug treatment if MA developed was: for anginotensin converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) 23-50% (depending on country), for statins 0-19%, for acetylsalicylic acid 2-13%, and for hypoglycemic agents (tablets and insulin) 0-33%. The proportion of GPs recommending all four possible treatment modalities was low.

CONCLUSIONS

Guidelines for diagnosing MA were partly followed. ACEIs and ARBs were recommended when MA was present, but the recommended multifactorial treatment of cardiovascular risk markers was not implemented.

摘要

目的

评估全科医生(GP)对诊断微量白蛋白尿(MA)的指南推荐的了解程度,并评估这一诊断如何影响糖尿病患者的药物治疗。

方法

采用基于病例的邮寄问卷形式,描述一位患有 2 型糖尿病的男性患者(之前未检测过 MA),他有几个心血管疾病的风险标志物。

结果

来自 9 个欧洲国家的 2078 名全科医生参与了研究,回复率从 7%到 43%不等。几乎所有的全科医生都建议每年检测 MA。45%至 77%(取决于国家)的全科医生需要多次阳性检测才能诊断 MA。如果出现 MA,会增加补充患者药物治疗的全科医生比例为:血管紧张素转换酶抑制剂(ACEI)或血管紧张素 II 受体阻滞剂(ARB)为 23%-50%(取决于国家),他汀类药物为 0%-19%,乙酰水杨酸为 2%-13%,降糖药(片剂和胰岛素)为 0%-33%。建议所有四种可能的治疗方法的全科医生比例较低。

结论

部分遵循了 MA 的诊断指南。当出现 MA 时,推荐使用 ACEI 和 ARB,但未实施推荐的心血管风险标志物的多因素治疗。

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