外周和/或冠状动脉疾病患者的主动脉瓣硬化

Aortic valve sclerosis in patients with peripheral and/or coronary arterial disease.

作者信息

Losi Maria-Angela, Brevetti Gregorio, Schiano Vittorio, Barbati Giovanni, Parisi Valentina, Contaldi Carla, Chiacchio Elena, Cavallaro Massimo, Carpinella Gerardo, Fundaliotis Angelica, Parrella Lucia-Serena, Betocchi Sandro, Brevetti Linda, Chiariello Massimo

机构信息

Department of Clinical Medicine, Cardiovascular & Immunological Sciences, Federico II University School of Medicine, Naples, Italy.

出版信息

Echocardiography. 2010 Jul;27(6):608-12. doi: 10.1111/j.1540-8175.2009.01109.x. Epub 2010 Apr 16.

DOI:10.1111/j.1540-8175.2009.01109.x

PMID:20412271

Abstract

BACKGROUND

Aortic valve sclerosis (AVS) is a marker of cardiovascular risk; its prevalence increases in elderly and in patients with hypertension and/or coronary arterial disease (CAD). There are no data available in patients with peripheral arterial disease (PAD) and with both CAD and PAD.

METHODS

To investigate the presence of AVS, 57 patients with stable CAD, 38 with PAD, and 62 with CAD + PAD where studied by echocardiography.

RESULTS

The prevalence of AVS progressively increased within groups (P = 0.005). The prevalence of AVS in PAD doubled that in CAD group (42.1% vs. 22.8%, P < 0.05). PAD patients had a 4.634 (95% CI: 1.02-17.88; P = 0.026) fold increased risk of AVS compared to CAD. Also CAD + PAD group had a higher prevalence of aortic sclerosis when compared to CAD group (50.8% vs. 22.8%, P = 0.001). CAD + PAD showed a 3.799 (95% CI: 1.26-11.45; P < 0 .01) fold greater risk of aortic sclerosis than CAD group. There were no differences in AVS prevalence between CAD + PAD and PAD group (50.8% vs. 42.1%; P = 0.36). Age was related to AVS in both analysis (PAD vs. CAD and CAD + PAD vs. CAD: OR = 1.09, 95% CI: 1.02-1.16, P = 0.011 and OR = 1.13, 95% CI: 1.07-1.21; P < 0.001) but no classical cardiovascular risk factors.

CONCLUSIONS

PAD patients have an elevated prevalence of AVS greater than CAD patients. In patients with both disease, the prevalence of AVS is similar to that of patients with PAD alone.

摘要

背景

主动脉瓣硬化（AVS）是心血管疾病风险的一个标志物；其患病率在老年人以及高血压和/或冠状动脉疾病（CAD）患者中有所增加。目前尚无关于外周动脉疾病（PAD）患者以及同时患有CAD和PAD患者的数据。

方法

为研究AVS的存在情况，对57例稳定型CAD患者、38例PAD患者和62例CAD + PAD患者进行了超声心动图检查。

结果

AVS的患病率在各组中逐渐升高（P = 0.005）。PAD组中AVS的患病率是CAD组的两倍（42.1%对22.8%，P < 0.05）。与CAD患者相比，PAD患者发生AVS的风险增加了4.634倍（95%可信区间：1.02 - 17.88；P = 0.026）。与CAD组相比，CAD + PAD组主动脉硬化的患病率也更高（50.8%对22.8%，P = 0.001）。CAD + PAD组发生主动脉硬化的风险比CAD组高3.799倍（95%可信区间：1.26 - 11.45；P < 0.01）。CAD + PAD组和PAD组之间的AVS患病率没有差异（50.8%对42.1%；P = 0.36）。在两项分析中，年龄均与AVS相关（PAD组对CAD组以及CAD + PAD组对CAD组：比值比 = 1.09，95%可信区间：1.02 - 1.16，P = 0.011；比值比 = 1.13，95%可信区间：1.07 - 1.21；P < 0.001），但与经典的心血管危险因素无关。