Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, Ljubljana, Slovenia.
Anaerobe. 2010 Aug;16(4):393-5. doi: 10.1016/j.anaerobe.2010.04.001. Epub 2010 Apr 20.
Clostridium difficile toxinotype XI strains do not produce toxins A (TcdA) or B (TcdB) but do possess a nonfunctional remnant of the pathogenicity locus (PaLoc), bearing part of the sequence for tcdA. This is the first report of a type with absent upstream terminal PaLoc sequences and major genetic rearrangements of the PaLoc region.
产艰难梭菌毒素 XI 型菌株不产生毒素 A(TcdA)或 B(TcdB),但确实具有致病性基因座(PaLoc)的无功能残余物,携带 tcdA 序列的一部分。这是首次报道缺失上游末端 PaLoc 序列和 PaLoc 区域主要遗传重排的类型。