Yuan Xiao-Jun, He Qi-Tu
Deparment of Hematology, The First Affiliated Hospital, Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Apr;18(2):515-9.
The occurrence and development of many tumors all relate with abnormal expression of the Notch receptor. The role of different Notch receptors may be different, even contrary in different tissues at different stages of tumor development, as well as in the same system tumors. Notch signaling pathway plays an important role in cell proliferation, differentiation, apoptosis and tumor angiogenesis, and is as a meeting point for many important cell signaling pathway. Angiogenesis is regulated by complex interactions of multiple activators and inhibitors. Vascular endothelial growth factor (VEGF) and Notch signaling pathway are involved in such process. Many studies have confirmed that Notch signaling pathway plays a key role in the embryonic development and tumour angiogenesis. Recent studies have also revealed that Notch signaling pathway has many potential drug targets. Based on study of Notch signaling pathway and its molecular mechanism of leukemia, to design drugs effecting these targets to block and activate Notch signaling pathway for therapy of leukemia and angiogenesis diseases has a broad application prospects. This review summarises the components of Notch signaling pathway and the role of Notch signaling pathway in occurrence of leukemia and angiogenesis.
许多肿瘤的发生和发展都与Notch受体的异常表达有关。不同的Notch受体在肿瘤发展的不同阶段，于不同组织以及同一系统肿瘤中的作用可能不同，甚至相反。Notch信号通路在细胞增殖、分化、凋亡和肿瘤血管生成中发挥重要作用，并且是许多重要细胞信号通路的交汇点。血管生成受多种激活剂和抑制剂的复杂相互作用调节。血管内皮生长因子（VEGF）和Notch信号通路参与此过程。许多研究证实，Notch信号通路在胚胎发育和肿瘤血管生成中起关键作用。最近的研究还表明，Notch信号通路有许多潜在的药物靶点。基于对Notch信号通路及其在白血病中的分子机制的研究，设计作用于这些靶点的药物以阻断和激活Notch信号通路用于白血病和血管生成疾病的治疗具有广阔的应用前景。本文综述了Notch信号通路的组成成分及其在白血病发生和血管生成中的作用。
