Pannone G, Sanguedolce F, Santoro A, Fierro P, Panetti M, Fierro D, Maiello F, De Maria S, Giannattasio A, Serpico R, Lo Muzio L, Metafora S, Bufo P
Department of Surgical Sciences, Institute of Pathology and Cytopathology, University of Foggia, Viale Pinto, Foggia, Italy.
Auris Nasus Larynx. 2010 Oct;37(5):648-50. doi: 10.1016/j.anl.2010.03.003. Epub 2010 Apr 22.
Human papilloma virus infection is thought to play a role in laryngeal carcinogenesis; the variable association reported in literature may be due to wide range of HPV genotypes. We report the case of a 51-year-old man affected by laryngeal squamous cell carcinoma; analysis of DNA extracted by cancer cells by an innovative molecular virology assay (INNO-LiPA HPV Genotyping Extra) showed the presence of two high-risk HPV genotypes, HPV-73 and -82. Immunohistochemical examination confirmed positivity for both capsid protein and viral oncogenic protein E7. Such association has never been reported in literature so far, and a brief discussion on the importance of assessing HPV status in laryngeal cancer is provided.
人乳头瘤病毒感染被认为在喉癌发生中起作用；文献中报道的可变关联可能归因于广泛的人乳头瘤病毒基因型。我们报告了一例51岁男性喉鳞状细胞癌病例；通过一种创新的分子病毒学检测方法（INNO-LiPA人乳头瘤病毒基因分型升级版）对癌细胞提取的DNA进行分析，结果显示存在两种高危人乳头瘤病毒基因型，即人乳头瘤病毒-73和-82。免疫组化检查证实衣壳蛋白和病毒致癌蛋白E7均呈阳性。迄今为止，这种关联在文献中从未有过报道，本文还对评估喉癌中人乳头瘤病毒状态的重要性进行了简要讨论。
