UB-8902 在人多形核白细胞中的细胞内渗透和活性。
Intracellular penetration and activity of UB-8902 in human polymorphonuclear leukocytes.
机构信息
Departmento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Seville, Spain.
出版信息
Enferm Infecc Microbiol Clin. 2010 Nov;28(9):612-4. doi: 10.1016/j.eimc.2009.11.014. Epub 2010 Apr 24.
The intracellular penetration and activity of UB-8902 in human polymorphonuclear leukocytes was evaluated. Intracellular UB-8902 concentrations were 6-fold higher than extracellular levels. Uptake was rapid, reversible, saturable, and affected by external pH. UB-8902 showed intracellular activity against Staphylococcus aureus strains presenting mutations associated with fluoroquinolone resistance in the gyrA and/or grlA genes.
研究了 UB-8902 在人多形核白细胞中的细胞内渗透和活性。细胞内 UB-8902 浓度比细胞外水平高 6 倍。摄取是快速、可逆、饱和的，并受外部 pH 值的影响。UB-8902 对携带 gyrA 和/或 grlA 基因中与氟喹诺酮耐药相关突变的金黄色葡萄球菌菌株具有细胞内活性。
Zotero 插件