DX-619在人多形核白细胞中的细胞内渗透及活性
Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes.
作者信息
García Isabel, Ballesta Sofía, Murillo Concepción, Perea Evelio J, Pascual Alvaro
机构信息
Department of Microbiology, School of Medicine, University of Seville, Seville-41009, Spain.
出版信息
Antimicrob Agents Chemother. 2006 Sep;50(9):3173-4. doi: 10.1128/AAC.00427-06.
Abstract
The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 reached intracellular concentrations 10 times higher than the extracellular concentrations reached. Uptake was rapid, reversible, nonsaturable, and affected by environmental temperature, some metabolic inhibitors, and a soluble membrane activator. DX-619 showed intracellular activity against Staphylococcus aureus.
摘要
已评估了DX - 619在人多形核白细胞中的细胞内渗透及活性。DX - 619在细胞内达到的浓度比细胞外浓度高10倍。摄取迅速、可逆、非饱和，且受环境温度、一些代谢抑制剂和一种可溶性膜激活剂的影响。DX - 619对金黄色葡萄球菌显示出细胞内活性。
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