Erecińska M, Wilson D F, Nishiki K
Am J Physiol. 1978 Mar;234(3):C82-9. doi: 10.1152/ajpcell.1978.234.3.C82.
Measurements in isolated liver cells, cultured kidney cells, protozoa (Tetrahymena pyriformis), and yeast (Candida utilis) indicate that homeostatic regulation of cellular energy metabolism is of common origin. In every case near equilibrium is maintained between the transfer of reducing equivalents from the intramitochondrial NAD couple to cytochrome c and the phosphorylation of cytosolic ADP to ATP. Under conditions of constant energy demand, changes in the intracellular phosphate concentration cause an adjustment in the [ATP]/[ADP] to maintain a constant [ATP]/[ADP][Pi] and constant respiratory rate. The regulation of mitochondrial respiration occurs as part of the reactions by which reduced cytochrome c is oxidized by molecular oxygen. At similar values for the [ATP]/[ADP][Pi] the respiratory rate increases with increasing reduction of cytochrome c. A model for mitochondrial respiratory control is found to give a good fit to the data in all of the different types of cells tested.
对分离的肝细胞、培养的肾细胞、原生动物（梨形四膜虫）和酵母（产朊假丝酵母）的测量表明，细胞能量代谢的稳态调节有着共同的起源。在每种情况下，从线粒体内NAD偶联物到细胞色素c的还原当量转移与胞质ADP磷酸化为ATP之间都维持着接近平衡的状态。在能量需求恒定的条件下，细胞内磷酸盐浓度的变化会导致[ATP]/[ADP]的调整，以维持恒定的[ATP]/[ADP][Pi]和恒定的呼吸速率。线粒体呼吸的调节是细胞色素c被分子氧氧化的反应的一部分。在[ATP]/[ADP][Pi]值相似时，呼吸速率随着细胞色素c还原程度的增加而增加。发现一种线粒体呼吸控制模型与所有测试的不同类型细胞中的数据都非常吻合。
