Kruaysawat Watcharin, Aekplakorn Wichai, Chapman Robert S
Srimuangmai Hospital, Ubon Ratchathani, Thailand.
J Med Assoc Thai. 2010 Mar;93(3):278-84.
To characterize the survival time and prognostic factors of oral cancer in Ubon Ratchathani, Thailand.
A total of 519 patients with oral cancer in the Ubon Ratchathani Cancer Center were recruited retrospectively over 5 years, from January 1, 2002 to December 31, 2006. The survival status of the patients was followed until December 31, 2007. Survival times were estimated and compared using the product-limit (Kaplan-Meier) method Cox Proportional Hazards models were used to examine prognostic factors.
At the end of the study, 384 patients (74.0%) had died. The mean age of the patients at diagnosis was 64.15 years, with a male to female ratio of 1:1.56. Location of cancer were found at tongue (25.2%), buccal mucosa (22.4%), gum (21.1%), lip (17.5%) and others (13.7%). Squamous cell carcinoma was the most common cell type (92.7%). The median survival time was 337 days and the survival probability at 1, 3 and 5-years were 46.7%, 26.4% and 18.2%, respectively. In multivariable analysis, patients at the greatest risk of death were those having cancer of the tongue (HR 1.93, 1.20, 3.11) compared to cancer of the lip and being in stage IV at diagnosis (HR 3.57, 95% CI = 1.79, 7.13) as compared to stage I.
Patients with advanced tumors had the worst prognosis, underscoring the importance of improved early detection for early treatment.
描述泰国乌汶叻差他尼口腔癌的生存时间及预后因素。
回顾性招募了2002年1月1日至2006年12月31日期间在乌汶叻差他尼癌症中心就诊的519例口腔癌患者。对患者的生存状况进行随访至2007年12月31日。采用乘积限（Kaplan-Meier）法估计和比较生存时间，使用Cox比例风险模型检验预后因素。
研究结束时，384例患者（74.0%）死亡。患者诊断时的平均年龄为64.15岁，男女比例为1:1.56。癌症发生部位为舌（25.2%）、颊黏膜（22.4%）、牙龈（21.1%）、唇（17.5%）及其他部位（13.7%）。鳞状细胞癌是最常见的细胞类型（92.7%）。中位生存时间为337天，1年、3年和5年的生存概率分别为46.7%、26.4%和18.2%。多变量分析显示，与唇癌相比，舌癌患者死亡风险最高（风险比1.93，95%可信区间为1.20, 3.11）；与I期相比，诊断时处于IV期的患者死亡风险最高（风险比3.57，95%可信区间为1.79, 7.13）。
晚期肿瘤患者预后最差，这突出了改善早期检测以进行早期治疗的重要性。
