Pazdernyik Szilárd, Sándor László, Elek Péter, Barzó Pál
Szegedi Tudományegyetem, Altalános Orvostudományi Kar, Idegsebészeti Klinika, Szeged.
Ideggyogy Sz. 2010 Jan 30;63(1-2):25-37.
Both acute and chronic instability of the cervical spine can be succesfully treated by anterior crevical fusion. The main goal is to create a spondylodesis through which the instable motion segments are fixed in the position defined by the surgeon. The spondylodesis is realised by the bone healing of the intervertebral space. The consolidation itself is facilitated by the operative stabilisation of the segments involved, and also by the implantation/transplantation of the osteoproductive/osteoinductive materials. The sooner consolidation is achieved, the more likely it is to be able to avoid the material dependent complications and/or that of dislocation. So as to support this theory a retrospective clinical/radiological study was performed. During this the length and the safety of the consolidation was measured by applying various anterior cervical plating systems. A total of 485 patients having cervical injuries or degenerative disc disease were treated by anterior cervical plating. For bone transplantation partly pure autolog spongious partly autolog cortico-spongious morsalised bone chips, furthermore autolog tricortical bone block were applied. A standard protocoll was used for data collection, evaluation and also follow-up. The patients treated with plate systems were divided into 3 groups: Group 1: Non-locked H-plate system with autogeneous cancellous bone (155 trauma patients, for a total of 210 cervical motion segments, 1.35 segments/patients). Group 2: Non-locked H-plate system with tricortical autograft (167 patients, for a total of 290 cervical motion segments, 1.73 segments/patients). Group 3: Locked cervical plate system with tricortical autograft (73 patients, for a total of 110 cervical motion segments, 1.5 segments/patients). Patients treated with standalone cage belong to group 4. These cages were filled with autogenous cortico-spongiosus bone chips (90 patients, for a total of 90 cervical motion segments, 1.0 segments/patients). Evaluations included postoperative clinical, X-ray and CT examination, and follow-ups at 6, 16, 52, and 104 weeks. We established three grades, and classified the degree of bony fusion between the graft and vertebra: not-yet-fused, fused or non-union. When evaluating the results the following statements/observations were made: a) There is a fast and safe consolidation in the case of those patients that underwent dinamic disc osteosynthesis (p = 0.00001). b) Whereas performing fixation with non-locked or locked screw plate systems and strutgrafted with tricortical autograft created prolonged healing requiring months and developed non-unions more often (non-locked screw-plate system versus locked screw-plate system) (p > 0.05). c) Using locked screw-plate fixation systems non-union rate in our study was 21%, suggesting that this form of fixation has only a limited use. d) In our study complete consolidation without pseudoarthrosis was achieved by using standalone cages filled with autolog cortico-spongiosus bone chips, but bony healing was delayed due to cage coating and the substitution of pure autogenous spongiosa for cortico-spongiosus bone chips. It is recommended to treat acute/chronic instability of the cervical spine both by using non-fixed plate system with autolog cancellosus bone and by standalone cage filled with cortico-spongiosus bone chips as well. It is worth keeping in mind that by applying this lattest an extra surgery to harvest the graft will be avoided.
颈椎的急性和慢性不稳定均可通过颈椎前路融合术成功治疗。主要目标是形成脊柱融合,通过该融合将不稳定的运动节段固定在外科医生确定的位置。脊柱融合通过椎间隙的骨愈合来实现。通过对受累节段进行手术稳定,以及植入/移植具有成骨/骨诱导作用的材料,可促进融合本身的发生。融合实现得越早,就越有可能避免与材料相关的并发症和/或脱位并发症。为支持这一理论,我们进行了一项回顾性临床/放射学研究。在此期间,通过应用各种颈椎前路钢板系统来测量融合的时长和安全性。共有485例颈椎损伤或退行性椎间盘疾病患者接受了颈椎前路钢板治疗。骨移植部分采用单纯自体松质骨,部分采用自体皮质 - 松质骨碎骨片,此外还应用了自体三面皮质骨块。使用标准方案进行数据收集、评估以及随访。接受钢板系统治疗的患者分为3组:第1组:采用自体松质骨的非锁定H型钢板系统(155例创伤患者,共210个颈椎运动节段,1.35个节段/患者)。第2组:采用三面皮质自体骨移植的非锁定H型钢板系统(167例患者,共290个颈椎运动节段,1.73个节段/患者)。第3组:采用三面皮质自体骨移植的锁定颈椎钢板系统(73例患者,共110个颈椎运动节段,1.5个节段/患者)。接受单独椎间融合器治疗的患者属于第4组。这些椎间融合器填充有自体皮质 - 松质骨碎骨片(90例患者,共90个颈椎运动节段,1.0个节段/患者)。评估包括术后临床、X线和CT检查,以及在6周、16周、52周和104周时的随访。我们设定了三个等级,并对移植骨与椎体之间的骨融合程度进行分类:未融合、融合或不愈合。在评估结果时,得出了以下陈述/观察结果:a)对于接受动态椎间盘骨合成的患者,存在快速且安全的融合(p = 0.00001)。b)而使用非锁定或锁定螺钉钢板系统进行固定并采用三面皮质自体骨移植时,愈合时间延长,需要数月,且不愈合更为常见(非锁定螺钉钢板系统与锁定螺钉钢板系统相比)(p > 0.05)。c)在我们的研究中,使用锁定螺钉钢板固定系统时不愈合率为21%,表明这种固定形式的应用有限。d)在我们的研究中,通过使用填充有自体皮质 - 松质骨碎骨片的单独椎间融合器实现了无假关节的完全融合,但由于椎间融合器涂层以及用单纯自体松质骨替代皮质 - 松质骨碎骨片,骨愈合延迟。建议采用带有自体松质骨的非固定钢板系统以及填充有皮质 - 松质骨碎骨片的单独椎间融合器来治疗颈椎的急性/慢性不稳定。值得记住的是,通过应用后者可避免额外的手术来获取移植骨。