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特立尼达蝙蝠感染塔卡里比病毒及虫媒病毒的血清学证据。

Serological evidence of infection of Tacaribe virus and arboviruses in Trinidadian bats.

作者信息

Price J L

出版信息

Am J Trop Med Hyg. 1978 Jan;27(1 Pt 1):162-7. doi: 10.4269/ajtmh.1978.27.162.

DOI:10.4269/ajtmh.1978.27.162
PMID:204207
Abstract

Sera from 39 species of bats collected in Trinidad between 1972 and 1974 were tested against some or all of 18 arboviruses in hemagglutination inhibition (HI) and/or suckling mouse neutralization (N) tests. A few sera were HI-positive with Mucambo, eastern equine encephalitis (EEE), Oriboca, Restan, Manzanilla, Guama, Bimiti, and Catu. No sera were HI-positive with Mayaro, Caraparu or Maguari. Many ser inhibited one or more of the group B hemagglutinins: Ilheus, St. Louis encephalitis (SLE), dengue 2, and yellow fever (YF), positives occurred in nearly every species of bat, being most frequent with Ilheus. In N tests, a few or single sera were found to protect against Ilheus, Nepuyo, Guama, Bimiti, and Cocal, while none protected against EEE, SLE, YF or Catu. Many sera positive in HI test with Ilheus, SLE or YF failed to neutralize the respective virus. Tacaribe neutralizing antibody was demonstrated in Artibeus jamaicensis and A. lituratus, the sources of past virus isolation, in the fruit bats Sturnira lilium and Vampyrops helleri, and in the vampire bat Desmodus rotundus. Sera from 19 other species gave either negative or inconclusive results. No convincing evidence of Tacaribe antibody was found in 29 human sera, 20 from bat collectors.

摘要

1972年至1974年间在特立尼达收集的39种蝙蝠的血清,针对18种虫媒病毒中的部分或全部,进行了血凝抑制(HI)和/或乳鼠中和(N)试验。少数血清对穆坎博病毒、东部马脑炎病毒(EEE)、奥里博卡病毒、雷斯坦病毒、曼萨尼拉病毒、瓜马病毒、比米蒂病毒和卡图病毒呈HI阳性。没有血清对马亚罗病毒、卡拉帕鲁病毒或马瓜里病毒呈HI阳性。许多血清抑制了B组血凝素中的一种或多种:伊列乌斯病毒、圣路易斯脑炎病毒(SLE)、登革热2型病毒和黄热病病毒(YF),几乎每种蝙蝠中都有阳性出现,以伊列乌斯病毒最为常见。在N试验中,发现少数或个别血清能抵御伊列乌斯病毒、内普约病毒、瓜马病毒、比米蒂病毒和科卡尔病毒,而没有血清能抵御EEE、SLE、YF或卡图病毒。许多在HI试验中对伊列乌斯病毒、SLE或YF呈阳性的血清未能中和相应病毒。在过去分离出病毒的 Jamaicensis 果蝠和 A. lituratus 果蝠、白喉叶鼻蝠和南美吸血蝠中,以及吸血蝙蝠中都检测到了塔卡里贝中和抗体。来自其他19个物种的血清结果为阴性或不确定。在29份人类血清中,包括20份来自蝙蝠采集者的血清,未发现有说服力的塔卡里贝抗体证据。

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