益生菌与万古霉素耐药肠球菌在人和小鼠肠道中的定植。
Probiotics and intestinal colonization by vancomycin-resistant enterococci in mice and humans.
机构信息
Service des maladies infectieuses et tropicales, CHU Clermont-Ferrand, Clermont-Ferrand, France.
出版信息
J Clin Microbiol. 2010 Jul;48(7):2595-8. doi: 10.1128/JCM.00473-10. Epub 2010 Apr 26.
Abstract
We investigated the impact of probiotics on the intestinal carriage of vancomycin-resistant enterococci (VRE). Administration of Lactobacillus rhamnosus Lcr35 but not Escherichia coli Nissle reduced, although not significantly, the density of VRE colonization in a murine model. No effect of Lcr35 was observed in a double-blind placebo randomized study, involving nine patients.
摘要
我们研究了益生菌对万古霉素耐药肠球菌（VRE）肠道携带的影响。鼠模型中，虽然利斯特氏乳杆菌 Lcr35 降低 VRE 定植密度的作用不显著，但确实有效；而雀巢肠球菌 Nissle 则没有这种效果。在一项涉及 9 名患者的双盲安慰剂随机研究中，未观察到 Lcr35 的效果。
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