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GG Versus Placebo for Eradication of Vancomycin-Resistant in Intestinal Carriers: A Systematic Review and Meta-Analysis.

作者信息

Rubin Ingrid Maria Cecilia, Knudsen Maja Johanne Søndergaard, Halkjær Sofie Ingdam, Ilsby Christian Schaadt, Pinholt Mette, Petersen Andreas Munk

机构信息

Department of Clinical Microbiology, Copenhagen University Hospital-Amager and Hvidovre, 2650 Hvidovre, Denmark.

Gastrounit, Medical Section, Copenhagen University Hospital-Amager and Hvidovre, 2650 Hvidovre, Denmark.

出版信息

Microorganisms. 2023 Nov 19;11(11):2804. doi: 10.3390/microorganisms11112804.


DOI:10.3390/microorganisms11112804
PMID:38004815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10673360/
Abstract

The aim of this review was to assess the efficacy and safety of GG (LGG) (previously known as GG) for the eradication of vancomycin-resistant (VREfm) in colonized carriers. We searched Cochrane Central, EMBASE, and the PubMed Library from inception to 21 August 2023, for randomized controlled trials (RCTs) investigating the effectiveness of LGG for the eradication of gastrointestinal carriage of VREfm. An initial screening was performed followed by a full-text evaluation of the papers. Out of 4076 articles in the original screening, six RCTs (167 participants) were included in the review. All were placebo-controlled RCTs. The meta-analysis was inconclusive with regard to the effect of LGG for clearing VREfm colonization. The overall quality of the evidence was low due to inconsistency and the small number of patients in the trials. We found insufficient evidence to support the use of LGG for the eradication of VREfm in colonized carriers. There is a need for larger RCTs with a standardized formulation and dosage of LGG in future trials.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5651/10673360/3d269bbc8e38/microorganisms-11-02804-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5651/10673360/62c84d4d693c/microorganisms-11-02804-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5651/10673360/9effc40132ca/microorganisms-11-02804-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5651/10673360/3d269bbc8e38/microorganisms-11-02804-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5651/10673360/62c84d4d693c/microorganisms-11-02804-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5651/10673360/9effc40132ca/microorganisms-11-02804-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5651/10673360/3d269bbc8e38/microorganisms-11-02804-g003.jpg

相似文献

[1]
GG Versus Placebo for Eradication of Vancomycin-Resistant in Intestinal Carriers: A Systematic Review and Meta-Analysis.

Microorganisms. 2023-11-19

[2]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
No Effect of Lactobacillus rhamnosus GG on Eradication of Colonization by Vancomycin-Resistant Enterococcus faecium or Microbiome Diversity in Hospitalized Adult Patients.

Microbiol Spectr. 2022-6-29

[2]
The use of core genome multilocus sequence typing to determine the duration of vancomycin-resistant Enterococcus faecium outbreaks.

APMIS. 2022-6

[3]
A randomized controlled trial of GG on antimicrobial-resistant organism colonization.

Infect Control Hosp Epidemiol. 2022-2

[4]
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.

BMJ. 2021-3-29

[5]
Gut Microbiota Predict Expansion but Not Vancomycin-Resistant Acquisition.

mSphere. 2020-11-18

[6]
Long-Lasting Decrease of the Acquisition of and Gram-Negative Bacteria Producing Extended Spectrum Beta-Lactamase (ESBL) by Transient Application of Probiotics.

Int J Environ Res Public Health. 2020-8-21

[7]
Tackling Antimicrobial Resistance by promoting Antimicrobial stewardship in Medical and Allied Health Professional Curricula.

Expert Rev Anti Infect Ther. 2020-12

[8]
A new use of GG administration in the NICU: colonized vancomycin-resistant enterococcus eradication in the gastrointestinal system.

J Matern Fetal Neonatal Med. 2022-3

[9]
Effect of probiotics on multi-resistant organism colonisation in persons with spinal cord injury: secondary outcome of ProSCIUTTU, a randomised placebo-controlled trial.

Spinal Cord. 2020-7

[10]
Loss of microbial diversity and pathogen domination of the gut microbiota in critically ill patients.

Microb Genom. 2019-9-11

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