Rubin Ingrid Maria Cecilia, Knudsen Maja Johanne Søndergaard, Halkjær Sofie Ingdam, Ilsby Christian Schaadt, Pinholt Mette, Petersen Andreas Munk
Department of Clinical Microbiology, Copenhagen University Hospital-Amager and Hvidovre, 2650 Hvidovre, Denmark.
Gastrounit, Medical Section, Copenhagen University Hospital-Amager and Hvidovre, 2650 Hvidovre, Denmark.
Microorganisms. 2023 Nov 19;11(11):2804. doi: 10.3390/microorganisms11112804.
The aim of this review was to assess the efficacy and safety of GG (LGG) (previously known as GG) for the eradication of vancomycin-resistant (VREfm) in colonized carriers. We searched Cochrane Central, EMBASE, and the PubMed Library from inception to 21 August 2023, for randomized controlled trials (RCTs) investigating the effectiveness of LGG for the eradication of gastrointestinal carriage of VREfm. An initial screening was performed followed by a full-text evaluation of the papers. Out of 4076 articles in the original screening, six RCTs (167 participants) were included in the review. All were placebo-controlled RCTs. The meta-analysis was inconclusive with regard to the effect of LGG for clearing VREfm colonization. The overall quality of the evidence was low due to inconsistency and the small number of patients in the trials. We found insufficient evidence to support the use of LGG for the eradication of VREfm in colonized carriers. There is a need for larger RCTs with a standardized formulation and dosage of LGG in future trials.
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