Choy Alexa, Freedberg Daniel E
Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY, USA.
Therap Adv Gastroenterol. 2020 Jul 17;13:1756284820939447. doi: 10.1177/1756284820939447. eCollection 2020.
In the intensive care unit (ICU), colonization of the gastrointestinal tract by potentially pathogenic bacteria is common and often precedes clinical infection. Though effective in the short term, traditional antibiotic-based decolonization methods may contribute to rising resistance in the long term. Novel therapies instead focus on restoring gut microbiome equilibrium to achieve pathogen colonization resistance. This review summarizes the existing data regarding microbiome-based approaches to gastrointestinal pathogen colonization in ICU patients with a focus on prebiotics, probiotics, and synbiotics.
在重症监护病房（ICU）中，潜在致病菌在胃肠道的定植很常见，且往往先于临床感染出现。尽管传统的基于抗生素的去定植方法在短期内有效，但从长期来看可能会导致耐药性增加。相反，新型疗法侧重于恢复肠道微生物群平衡以实现对病原体定植的抵抗。本综述总结了有关基于微生物群的方法用于ICU患者胃肠道病原体定植的现有数据，重点关注益生元、益生菌和合生元。
