Department of Veterinary Biosciences, University of Illinois, Urbana, IL 61802, USA.
Mol Reprod Dev. 2010 Jun;77(6):489-96. doi: 10.1002/mrd.21174.
Adrenal, testis, and ovary are steroidogenic organs derived from a common primordium that consists of steroidogenic factor 1 (SF1)-positive precursor cells. SF1 not only defines the steroidogenic lineages in these organs but also controls their differentiation. Recent evidence implicates the Hedgehog (Hh) signaling pathway as a downstream regulator of SF1 in the appearance of steroidogenic cells in these organs. The Hh signaling pathway serves as a common crosstalk component, yet has evolved diverse functions in the expansion and differentiation of the steroidogenic cells in a tissue-specific manner. The purpose of this review is to compare and contrast the different roles of Hh signaling in these three organs during development.
肾上腺、睾丸和卵巢是源自共同原始细胞的类固醇生成器官，该原始细胞包含类固醇生成因子 1（SF1）阳性前体细胞。SF1 不仅定义了这些器官中的类固醇生成谱系，还控制其分化。最近的证据表明，Hedgehog（Hh）信号通路是这些器官中类固醇生成细胞出现时 SF1 的下游调节剂。Hh 信号通路作为一个通用的串扰成分，以组织特异性的方式在类固醇生成细胞的扩增和分化中发挥了多样化的功能。本综述的目的是比较和对比 Hh 信号在这三个器官发育过程中的不同作用。
