醒脑静中影响栀子提取物肠道吸收的成分研究
[Study of components in xingnaojing affecting intestine absorption of gardenia extract].
作者信息
Du Shouying, Zhang Qianyi, Lu Yang, Zhai Yongsong, Wu Qing
机构信息
School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2010 Feb;35(3):297-300. doi: 10.4268/cjcmm20100309.
OBJECTIVE
To observe the influence of ingredients in Xingnaojing,such as moschus, borneol and radix curcumae on intestine absorption kinetics of gardenia extract.
METHOD
An in situ intestinal perfusion model of rats was employed to investigate the absorption of geniposide in gardenia extract.
RESULT
While gardenia extract was administered solely, the absorptive rate constant (K) of geniposide was (0.055 +/- 0.006) h(-1); But while the extract was co-administered with radix curcumae,moschus and borneol, the K were (0.060 +/- 0.001), (0.066 +/- 0.008), (0.072 +/- 0.010) h(-1), respectively. The K was (0.076 +/- 0.011) h(-1) while the extract in total formulation for Xingnaojing.
CONCLUSION
The K, while the extract is co-administered with borneol or total formulation is significantly higher than solely used. Borneol and complex prescription can significantly increase the intestinal absorption of geniposide in gardenia extract.
目的
观察醒脑静中的麝香、冰片、郁金等成分对栀子提取物肠道吸收动力学的影响。
方法
采用大鼠在体肠灌流模型考察栀子提取物中栀子苷的吸收情况。
结果
单独给予栀子提取物时，栀子苷的吸收速率常数（K）为（0.055±0.006）h⁻¹；与郁金、麝香、冰片合用时，K分别为（0.060±0.001）、（0.066±0.008）、（0.072±0.010）h⁻¹；醒脑静全方制剂时K为（0.076±0.011）h⁻¹。
结论
栀子提取物与冰片合用时及醒脑静全方制剂时的K显著高于单独使用时。冰片及复方制剂能显著提高栀子提取物中栀子苷的肠道吸收。
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