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吴茱萸提取物致老年胃癌患者胃体缩小

Shrinkage of gastric cancer in an elderly patient who received Rhus verniciflua Stokes extract.

机构信息

Department of Internal Medicine, Mu Integrative Cancer Center, East-West Neo Medical Center, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea.

出版信息

J Altern Complement Med. 2010 Apr;16(4):497-500. doi: 10.1089/acm.2008.0237.

DOI:10.1089/acm.2008.0237
PMID:20423218
Abstract

BACKGROUND

Many studies have suggested that the flavonoids from Rhus verniciflua Stokes (RVS) are anticancer agents, but a few clinical studies have reported on this topic.

PATIENT AND METHOD

We present here the case of a female patient (82 years old) with an adenocarcinoma of the stomach that was first diagnosed via an abdomen computed tomography (CT) scan and endoscopic biopsy. Any conventional therapy such as surgical resection was not performed because of her advanced age. She wanted to receive alternative care, and so she was exclusively treated with standardized RVS extract. COURSE OF THERAPY AND RESULTS: Daily therapy with 900 mg of orally administered RVS extract was initiated on September 25, 2006. Five (5) months later, the gastroscopy and abdomen CT scan showed a marked decrease in the polypoid mass at the mid body and a slight decrease in the flat elevated lesion at the prepyloric antrum, as compared to tumor sizes on the first gastroscopy and abdomen CT scan. She is alive and doing well at the present time (April 2009).

CONCLUSIONS

We suggest that RVS extract could be a candidate for a natural agent that induces selective apoptosis and inhibits cell growth in gastric adenocarcinoma.

摘要

背景

许多研究表明漆树(Rhus verniciflua Stokes)中的类黄酮是一种抗癌剂,但仅有少数临床研究对此进行了报道。

病例和方法

我们在此报告了一例女性胃腺癌患者的病例,该患者最初通过腹部 CT 扫描和内镜活检诊断出患有该病。由于患者年龄较大,未进行任何常规治疗,如手术切除。她希望接受替代治疗,因此仅接受标准化的漆树提取物治疗。

治疗经过及结果

自 2006 年 9 月 25 日起,开始每日口服 900mg 漆树提取物进行治疗。5 个月后,与第一次胃镜和腹部 CT 扫描相比,胃内窥镜和腹部 CT 扫描显示中体部的息肉样肿块明显缩小,胃前幽门的扁平隆起性病变略有缩小。目前(2009 年 4 月),该患者仍存活且状况良好。

结论

我们认为漆树提取物可能是一种天然药物候选物,可诱导胃腺癌的选择性细胞凋亡并抑制细胞生长。

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