Department of Infectious and Parasitic Diseases, Bacteriology, Faculty of Veterinary Medicine, University of Liège, Liège B4000, Belgium.
Vet Res. 2010 Sep-Oct;41(5):57. doi: 10.1051/vetres/2010029. Epub 2010 Apr 29.
Initial adherence to host cells is the first step of the infection of enteropathogenic Escherichia coli (EPEC), enterohaemorrhagic Escherichia coli (EHEC) and verotoxigenic Escherichia coli (VTEC) strains. The importance of this step in the infection resides in the fact that (1) adherence is the first contact between bacteria and intestinal cells without which the other steps cannot occur and (2) adherence is the basis of host specificity for a lot of pathogens. This review describes the initial adhesins of the EPEC, EHEC and VTEC strains. During the last few years, several new adhesins and putative colonisation factors have been described, especially in EHEC strains. Only a few adhesins (BfpA, AF/R1, AF/R2, Ral, F18 adhesins) appear to be host and pathotype specific. The others are found in more than one species and/or pathotype (EPEC, EHEC, VTEC). Initial adherence of EPEC, EHEC and VTEC strains to host cells is probably mediated by multiple mechanisms.
初始黏附宿主细胞是肠致病性大肠杆菌（EPEC）、肠出血性大肠杆菌（EHEC）和产毒性大肠杆菌（VTEC）菌株感染的第一步。这一步在感染中的重要性在于：（1）黏附是细菌与肠道细胞的第一次接触，如果没有这种接触，其他步骤就无法发生；（2）黏附是许多病原体宿主特异性的基础。本综述描述了 EPEC、EHEC 和 VTEC 菌株的初始黏附素。在过去的几年中，已经描述了几种新的黏附素和假定的定植因子，特别是在 EHEC 菌株中。只有少数黏附素（BfpA、AF/R1、AF/R2、Ral、F18 黏附素）似乎具有宿主和血清型特异性。其他黏附素存在于一种以上的物种和/或血清型（EPEC、EHEC、VTEC）中。EPEC、EHEC 和 VTEC 菌株对宿主细胞的初始黏附可能是由多种机制介导的。
