The Neurologic Group of Bucks/Montgomery County, 800 West State Street, Suite 101, Doylestown, PA 18901, USA.
Curr Neurol Neurosci Rep. 2010 Mar;10(2):140-6. doi: 10.1007/s11910-010-0087-5.
Chronic migraine (CM) is the leading cause of chronic daily headache, a common and debilitating headache syndrome. The management of CM patients is challenging, with only limited benefit from available oral preventive medications. Botulinum neurotoxin (BoNT) has been used extensively to treat disorders associated with increased muscle tone. More recent scientific data support an analgesic effect of the toxin. The pharmacokinetic and pharmacodynamic profiles of BoNT make it an appealing candidate for migraine prevention. Results from older clinical trials on the efficacy of the toxin in CM were inconclusive. However, recent trials using more stringent inclusion criteria have shown positive results, supporting the use of the toxin in some patients with this disorder. This review summarizes the scientific data on the analgesic properties of BoNT, as well as the clinical data on the efficacy of the toxin in treating CM.
慢性偏头痛（CM）是慢性每日头痛的主要原因，是一种常见且使人虚弱的头痛综合征。CM 患者的管理具有挑战性，现有口服预防药物的疗效有限。肉毒毒素（BoNT）已广泛用于治疗与肌肉张力增加相关的疾病。最近的科学数据支持毒素具有镇痛作用。BoNT 的药代动力学和药效学特征使其成为预防偏头痛的有吸引力的候选药物。关于毒素在 CM 中的疗效的早期临床试验结果不确定。然而，最近使用更严格纳入标准的试验显示出积极的结果，支持在一些患有这种疾病的患者中使用该毒素。这篇综述总结了 BoNT 的镇痛特性的科学数据，以及毒素治疗 CM 的临床数据。
