Department of Clinical Neuroscience, Headache Unit, C. Besta Neurological Institute and Foundation, Via Celoria, 11, 20133, Milan, Italy.
Neurol Sci. 2013 May;34 Suppl 1:S27-8. doi: 10.1007/s10072-013-1381-1.
Chronic migraine is a common and debilitating headache syndrome. Botulinum neurotoxin (BoNT), a potent toxin produced by the anaerobic bacterium Clostridium botulinum, used largely for treatment of disorders associated with increased muscle tone and hyperidrosis, has been recently used for patients suffering from chronic migraine. In this study, two groups of patients were treated with different dosages of BoNT A to verify the efficacy for chronic migraine. The results confirmed the efficacy of BoNT A when used at the dosage of 150 U. In the second group of patients treated with 100 U, results were not significant. Although these results are preliminary, they led to intense efforts to evaluate the analgesic properties of BoNT A and to assess their clinical applicability.
慢性偏头痛是一种常见且使人虚弱的头痛综合征。肉毒神经毒素（BoNT）是一种由厌氧细菌肉毒梭菌产生的强效毒素，主要用于治疗与肌肉张力增加和多汗症相关的疾病，最近已用于治疗慢性偏头痛患者。在这项研究中，两组患者分别接受不同剂量的 BoNT A 治疗，以验证其对慢性偏头痛的疗效。结果证实了 150U 剂量的 BoNT A 的疗效。而在接受 100U 剂量的第二组患者中，结果并不显著。尽管这些结果是初步的，但它们促使人们积极评估 BoNT A 的镇痛特性，并评估其临床适用性。
