Department of Surgery II, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Surg Today. 2010 May;40(5):404-10. doi: 10.1007/s00595-009-4120-8. Epub 2010 Apr 28.
Current treatment modalities of surgical resection and chemotherapy against cancers have improved survival. However, mortality from tumor recurrence remains high. Immunotherapy and gene therapy are potential additions to the treatment arsenal in the care of cancer patients. These novel therapeutic approaches need further investigation in in vitro and in vivo models as they are developed for potential use in humans. Here we reviewed immunotherapies and gene therapies that included clinical trials against cancers (mainly focusing on pancreatic cancer) suggesting the strong possibility of using these novel approaches.
目前，针对癌症的手术切除和化疗治疗方法已经提高了生存率。然而，肿瘤复发导致的死亡率仍然很高。免疫疗法和基因疗法是癌症患者治疗方案中的潜在补充手段。这些新的治疗方法需要在体外和体内模型中进一步研究，因为它们是为人类潜在应用而开发的。在这里，我们综述了针对癌症（主要集中在胰腺癌）的临床试验中包含的免疫疗法和基因疗法，这些研究表明了使用这些新方法的可能性。
