Sukhatme V P
Department of Medicine (Nephrology), Howard Hughes Medical Institute, Chicago, IL 60637.
Am J Kidney Dis. 1991 Jun;17(6):615-8. doi: 10.1016/s0272-6386(12)80333-7.
Extracellular ligands regulate the induction of several genes without the need for de novo protein synthesis. A subset of these so-called immediate-early response genes (IEG) encode transcription factors. This report focuses on the Egr group of zinc finger transcription factors. Their characterization should provide important insights into how cells respond to diverse extracellular signals.
细胞外配体无需从头合成蛋白质就能调节多种基因的诱导。这些所谓的立即早期反应基因(IEG)中的一部分编码转录因子。本报告聚焦于锌指转录因子的Egr家族。对它们的特性进行研究应能为细胞如何响应多种细胞外信号提供重要见解。