与多粘菌素B给药相关的高氯血症和阴离子间隙负值。
Hyperchloremia and negative anion gap associated with polymyxin B administration.
作者信息
O'Connor D T, Stone R A
出版信息
Arch Intern Med. 1978 Mar;138(3):478-80.
PMID:204265
Abstract
A patient receiving polymyxin B sulfate intravenously for Gram-negative "anion gap". Both abnormalities resolved following discontinuation of the drug. In vitro investigation suggested that the electrolyte abnormalities resulted from the polycationic properties of polymyxin B.
摘要
一名患者因革兰氏阴性菌感染接受静脉注射硫酸多粘菌素B后出现“阴离子间隙”异常。停用该药物后，这两种异常情况均得到缓解。体外研究表明，电解质异常是由多粘菌素B的聚阳离子特性导致的。
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