硫酸多粘菌素B对小鼠实验性雷氏变形杆菌感染的致死作用。
Lethal effect of polymyxin B sulfate in experimental Proteus rettgeri infection in mice.
作者信息
Bannatyne R M, Cheung R
出版信息
Can J Microbiol. 1980 Feb;26(2):254-6. doi: 10.1139/m80-039.
DOI:10.1139/m80-039
PMID:6250690
Abstract
The mouse model of intraperitoneal sepsis with Proteus rettgeri was used to evaluate the anti-endotoxic effect of polymyxin B sulfate. An unexpected reversal of the usual protective effect of polymyxin in experimental enterobacterial sepsis was observed in which the lethality of the infection was enhanced.
摘要
使用雷氏变形杆菌腹膜内脓毒症小鼠模型来评估硫酸多粘菌素B的抗内毒素作用。观察到在实验性肠杆菌脓毒症中多粘菌素通常的保护作用出现意外逆转，感染的致死率增加。
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