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超声促进 Sm(ClO(4))(3)催化合成新型 4-(2-苯基-1,2,3-三唑-4-基)-3,4-二氢嘧啶-(1H)-(硫酮)

Ultrasound-assisted synthesis of novel 4-(2-phenyl-1,2,3-triazol-4-yl)-3,4-dihydropyrimidin-(1H)-(thio)ones catalyzed by Sm(ClO(4))(3).

机构信息

School of Science, Xi'an Jiaotong University, Xi'an, China.

出版信息

Molecules. 2010 Mar 24;15(4):2087-95. doi: 10.3390/molecules15042087.

Abstract

An efficient synthesis of novel 4-(2-phenyl-1,2,3-triazol-4-yl)-3,4-dihydro-pyrimidin-2(1H)-(thio)ones from 1,3-dicarbonyl compounds, 2-phenyl-1,2,3-triazole-4-carbaldehyde and urea or thiourea under ultrasound irradiation and using samarium perchlorate as catalyst is described. Compared with conventional methods, the main advantages of the present methodology are milder conditions, shorter reaction times and higher yields.

摘要

在超声辐射下,以高氯酸钐为催化剂,由 1,3-二羰基化合物、2-苯基-1,2,3-三唑-4-甲醛和脲或硫脲合成新型 4-(2-苯基-1,2,3-三唑-4-基)-3,4-二氢嘧啶-2(1H)-(硫代)酮的方法。与传统方法相比,本方法的主要优点是条件温和、反应时间短、产率高。

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