使用新型手性镱催化剂的高度对映选择性Biginelli反应：二氢嘧啶的不对称合成
Highly enantioselective Biginelli reaction using a new chiral ytterbium catalyst: asymmetric synthesis of dihydropyrimidines.
作者信息
Huang Yijun, Yang Fengyue, Zhu Chengjian
机构信息
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
出版信息
J Am Chem Soc. 2005 Nov 30;127(47):16386-7. doi: 10.1021/ja056092f.
The highly enantioselective three-component Biginelli condensation catalyzed by a recyclable chiral ytterbium triflate with a novel hexadentate amine phenol ligand containing a pyridyl group has been developed. A wide range of optically active dihydropyrimidines with remarkable pharmacological interest was obtained in high yields with good to excellent enantioselectivities under mild conditions.
已开发出一种由可回收的手性三氟甲磺酸镱与含吡啶基的新型六齿胺基苯酚配体催化的高度对映选择性三组分Biginelli缩合反应。在温和条件下，以高收率和良好至优异的对映选择性获得了一系列具有显著药理活性的光学活性二氢嘧啶。
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