心血管造影术后血浆心钠素的变化
Changes in plasma atrial natriuretic peptide after angiocardiography.
作者信息
Osada M, Takeda S, Ogawa R, Iida T, Umetani K, Sawanobori T, Ijiri H, Komori S, Tamura K, Kugiyama K
机构信息
2nd Department of Internal Medicine, Yamanashi Medical University, Yamanashi, Japan.
出版信息
Exp Clin Cardiol. 2001 Winter;6(4):211-3.
BACKGROUND
Angiocardiography is an important diagnostic modality for evaluation of heart disease. It is well known that the concentration of plasma atrial natriuretic peptide (ANP) increases after injection of contrast medium. On the other hand, some patients with hypertension, heart failure or cardiac hypertrophy have an increased plasma ANP concentration at baseline; however, whether ANP increases after angiography in these patients is unknown.
OBJECTIVES
To investigate changes in plasma ANP concentrations after angiocardiography in patients with high ANP concentrations at baseline.
PATIENTS AND METHODS
Plasma ANP concentrations of 32 patients with angina pectoris were measured before and after angiocardiography. They were then classified into two groups according to their ANP concentration before examination.
RESULTS
ANP concentration after the injection of contrast medium increased significantly in patients with normal ANP concentrations before angiography but did not change in patients with high ANP concentrations at rest.
CONCLUSIONS
These results suggest that the absence of an increase in ANP after angiography may in part be due to reduced sensitivity to the angiography stimulus or to an already maximal activation of ANP secretion at baseline.
背景
心血管造影术是评估心脏病的重要诊断方法。众所周知，注射造影剂后血浆心钠素（ANP）浓度会升高。另一方面，一些高血压、心力衰竭或心脏肥大患者在基线时血浆ANP浓度就升高；然而，这些患者在血管造影术后ANP是否会升高尚不清楚。
目的
研究基线时ANP浓度较高的患者在心血管造影术后血浆ANP浓度的变化。
患者和方法
测量32例心绞痛患者在心血管造影术前和术后的血浆ANP浓度。然后根据检查前的ANP浓度将他们分为两组。
结果
血管造影术前ANP浓度正常的患者注射造影剂后ANP浓度显著升高，但静息时ANP浓度高的患者则无变化。
结论
这些结果表明，血管造影术后ANP不升高可能部分是由于对血管造影刺激的敏感性降低或基线时ANP分泌已处于最大激活状态。
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