Sansone Randy A, Sansone Lori A
Dr. R. Sansone is a Professor in the Departments of Psychiatry and Internal Medicine at Wright State University School of Medicine in Dayton, Ohio, and Director of Psychiatry Education at Kettering Medical Center in Kettering, Ohio.
Psychiatry (Edgmont). 2007 Nov;4(11):65-8.
Duloxetine is the newest addition to the US antidepressant market. In this case series, we describe what appears to be an unusual adverse reaction to duloxetine: an acute dysphoric response. This response occurred in five patients (four women and one man, all outpatients, ages 37-73 years) and manifested with either the initiation of the medication or during a dosage increase (all doses were 60mg per day or less). Among all patients, this unexpected response promptly subsided with either a dosage reduction or discontinuation of the medication. These observations suggest that a small minority of patients taking duloxetine may develop acute and dysphoric responses to the medication, which may be addressed with either a dosage reduction or discontinuation of duloxetine.
度洛西汀是美国抗抑郁药市场上的最新药物。在本病例系列中，我们描述了一种似乎不常见的度洛西汀不良反应：急性烦躁反应。这种反应发生在5名患者（4名女性和1名男性，均为门诊患者，年龄37 - 73岁）中，在开始用药或剂量增加期间出现（所有剂量均为每日60毫克或更低）。在所有患者中，这种意外反应通过减少剂量或停药迅速消退。这些观察结果表明，一小部分服用度洛西汀的患者可能会对该药物产生急性烦躁反应，这可以通过减少度洛西汀剂量或停药来解决。
