基于直线加速器的立体定向放射治疗和放射外科在神经外科患者治疗中的应用

[Linear accelerator-based stereotactic radiotherapy and radiosurgery in treatment of neurosurgical patients].

作者信息

Konovalov A N, Golanov A V, Gorlachev G E, Kornienko V N, Trunin Iu Iu, Kotel'nikova T M, Zolotova S V, Andronov A V, Kozlov A V, Galkin M V, Fil'chenkova N A, Mariashev S A, Pronin I N, Arutiunov N V, Lubnin A Iu, Soboleva O I, Nikotin K V, Iakovlev S B

出版信息

Zh Vopr Neirokhir Im N N Burdenko. 2010 Jan-Mar(1):4-12.

PMID:20429359

Abstract

Radiation methods are essential in management of certain types of neurooncological, neurovascular and functional brain pathology. Application of stereotactic technique of irradiation allows sufficient damaging impact on target (tumor, AVM, functional structures) and maximal protection of surrounding brain tissues. Indications to radiation treatment of intracranial lesions are expanding with evolution of stereotactic methods. The paper deals with the first experience of linear accelerator-based treatment of patients with intracranial neurosurgical pathology in this country. Techniques of stereotactic radiotherapy (SRT) and radiosurgery (SRS), indications to SRS and SRT in different modes of fractioning are described in details. Additionally specific complications, radiation reactions and feasibility of neurovisualization in diagnosis of radiation-induced brain damage are discussed.

摘要

放射治疗方法在某些类型的神经肿瘤学、神经血管和功能性脑疾病的治疗中至关重要。立体定向放射技术的应用能够对靶点（肿瘤、动静脉畸形、功能结构）产生足够的损伤作用，同时最大程度地保护周围脑组织。随着立体定向方法的发展，颅内病变放射治疗的适应证不断扩大。本文介绍了该国基于直线加速器治疗颅内神经外科疾病患者的首次经验。详细描述了立体定向放射治疗（SRT）和放射外科（SRS）技术，以及不同分割模式下SRS和SRT的适应证。此外，还讨论了特定并发症、放射反应以及神经影像学在诊断放射性脑损伤中的可行性。