Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
J Exp Clin Cancer Res. 2010 Apr 29;29(1):40. doi: 10.1186/1756-9966-29-40.
The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC). Although EGFR and Her-2 are frequently overexpressed in OSCC, few studies evaluated these proteins in saliva and their association with the tumor, which may represent potential usefulness in a clinical setting.
The levels of EGFR, Her-2, and EGF were evaluated in saliva of 46 patients with OSCC before and after the surgical removal of the lesion, as well as in matched healthy controls. The relationship of salivary levels and EGFR and Her-2 immunoexpression in tumor samples with clinicopathological features was analyzed.
EGFR and Her-2 salivary levels did not show difference between to pre-surgery and control groups, however, both demonstrated an increase after surgical removal of the tumor. No association was detectable among receptor salivary levels, tissue expression and clinicopathological features. EGF levels in pre-surgery group were significantly lower when compared to the control group.
EGFR and Her-2 were not considered to be valuable salivary tumor markers in OSCC, however, lower levels of EGF in saliva may suggest a higher susceptibility for OSCC development.
erbB 受体及其配体参与口腔鳞状细胞癌（OSCC）的发病机制和进展。虽然 EGFR 和 Her-2 在 OSCC 中经常过表达，但很少有研究评估这些蛋白在唾液中的表达及其与肿瘤的关系，这在临床环境中可能具有潜在的应用价值。
评估了 46 例 OSCC 患者手术切除肿瘤前后及匹配的健康对照组的唾液中 EGFR、Her-2 和 EGF 的水平。分析了唾液水平与肿瘤组织中 EGFR 和 Her-2 免疫表达的关系与临床病理特征。
EGFR 和 Her-2 的唾液水平在术前和对照组之间没有差异，但在肿瘤切除后均有升高。受体唾液水平、组织表达与临床病理特征之间无相关性。与对照组相比，术前组 EGF 水平显著降低。
EGFR 和 Her-2 被认为不是 OSCC 有价值的唾液肿瘤标志物，但唾液中 EGF 水平较低可能提示 OSCC 发展的易感性更高。
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