Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, The University of Sheffield, Sheffield, UK.
J Oral Pathol Med. 2018 Jan;47(1):32-39. doi: 10.1111/jop.12601. Epub 2017 Aug 4.
Oral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide, and the clinical and behavioral characteristics of tumors in this group are controversial, and the literature shows divergent results.
To investigate the clinicopathological features and prognostic significance of the immunoexpression of cell cycle and local invasion proteins in OSCC affecting young patients (≤40 years old).
A tissue microarray was performed with 132 OSCC samples (61 cases of young patients vs 71 cases of elderly patients) and submitted to immunohistochemical reactions with Ki67, p53, p16, Bcl-2, Cyclin D1, C-ErbB2, p21, Myc, EGFR, MMP-9, SMA, Cathepsin K and FGF-2 antibodies.
Clinicopathological features and survival rates were similar in both groups. Although overexpression of EGFR (P=.042) and MMP-9 (P=.001) was more frequent in young patients, only C-ErbB-2 (P=.048) and SMA (P=.048) expression correlated with lower disease-free survival (DFS) in this group of patients.
Clinicopathological features and survival rates are similar between younger and older patients with OSCC. The different patterns of C-ErbB2, EGFR, MMP-9, and SMA expression between the groups merits further investigation to understand their role in the early tumor onset in young patients.
口腔鳞状细胞癌（OSCC）主要影响 50 岁左右的男性；然而，据世界范围内报道，年轻患者的发病率有所增加，且该组肿瘤的临床和行为特征存在争议，文献结果也存在差异。
研究影响年轻患者（≤40 岁）的 OSCC 中细胞周期和局部侵袭蛋白免疫表达的临床病理特征及预后意义。
对 132 例 OSCC 样本（61 例年轻患者与 71 例老年患者）进行组织微阵列分析，并进行 Ki67、p53、p16、Bcl-2、Cyclin D1、C-ErbB2、p21、Myc、EGFR、MMP-9、SMA、组织蛋白酶 K 和 FGF-2 抗体的免疫组织化学反应。
两组患者的临床病理特征和生存率相似。虽然年轻患者中 EGFR（P=.042）和 MMP-9（P=.001）的过表达更为常见，但仅 C-ErbB-2（P=.048）和 SMA（P=.048）的表达与该组患者无病生存率（DFS）降低相关。
年轻和老年 OSCC 患者的临床病理特征和生存率相似。两组之间 C-ErbB2、EGFR、MMP-9 和 SMA 表达模式的不同值得进一步研究，以了解其在年轻患者肿瘤早期发病中的作用。
