Levine M R, Chu A, Abdul-Karim F W
Division of Ophthalmology, Mt. Sinai Medical Center, Cleveland, Ohio.
Arch Ophthalmol. 1991 Jun;109(6):847-9. doi: 10.1001/archopht.1991.01080060111036.
Brown tumor is a focal, bony lesion of hyperparathyroidism that results from parathyroid hormone on bone increasing osteoclastic activity with bone resorption and trabecular fibrosis. This leads to microfractures and hemorrhage and the appearance of brown tumors, which are seen most commonly in primary hyperparathyroidism and less frequently in secondary hyperparathyroidism. Rarely do these tumors involve the orbit. We report the sixth case, to our knowledge, of orbital involvement, in a patient with chronic renal failure (secondary hyperparathyroidism) and review the literature.
棕色瘤是甲状旁腺功能亢进引起的一种局限性骨病变，甲状旁腺激素作用于骨骼，增加破骨细胞活性，导致骨吸收和小梁纤维化。这会引发微骨折和出血，进而出现棕色瘤，棕色瘤最常见于原发性甲状旁腺功能亢进，较少见于继发性甲状旁腺功能亢进。这些肿瘤很少累及眼眶。据我们所知，我们报告了第六例眼眶受累病例，该病例发生在一名患有慢性肾衰竭（继发性甲状旁腺功能亢进）的患者身上，并对相关文献进行了综述。
