Parrish C M, O'Day D M
Arch Ophthalmol. 1986 Aug;104(8):1199-202. doi: 10.1001/archopht.1986.01050200105061.
Brown tumors, focal bony lesions of hyperparathyroidism, result from the direct effect of parathyroid hormone on bone. While such lesions are not uncommon in primary hyperparathyroidism, brown tumors have been associated less frequently with secondary hyperparathyroidism and have rarely been described as involving the orbital bones. We have found only four such cases previously reported in the ophthalmic literature. We report a case of orbital involvement by brown tumor in a child with chronic renal failure and secondary hyperparathyroidism. Use of long-term hemodialysis has increased the life span of individuals with chronic renal failure and produced an increased population of patients with secondary hyperparathyroidism and resultant bony changes. The ophthalmologist should consider brown tumor in the differential diagnosis of a patient with chronic renal failure and ocular symptomatology.
棕色瘤是甲状旁腺功能亢进引起的局限性骨病变，由甲状旁腺激素对骨骼的直接作用所致。虽然此类病变在原发性甲状旁腺功能亢进中并不少见，但棕色瘤与继发性甲状旁腺功能亢进的关联较少，且很少被描述为累及眶骨。我们在眼科文献中仅发现此前报道的4例此类病例。我们报告1例患有慢性肾衰竭和继发性甲状旁腺功能亢进的儿童发生棕色瘤累及眼眶的病例。长期血液透析的应用延长了慢性肾衰竭患者的寿命，并导致继发性甲状旁腺功能亢进患者群体增加以及由此产生的骨改变。眼科医生在对患有慢性肾衰竭和眼部症状的患者进行鉴别诊断时应考虑棕色瘤。
