脂质磷酸盐磷酸酶活性调节果蝇胚胎生殖细胞的分散和双侧分拣。
Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila.
机构信息
HHMI and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
出版信息
Development. 2010 Jun;137(11):1815-23. doi: 10.1242/dev.046110. Epub 2010 Apr 28.
In Drosophila, germ cell survival and directionality of migration are controlled by two lipid phosphate phosphatases (LPP), wunen (wun) and wunen-2 (wun2). wun wun2 double mutant analysis reveals that the two genes, hereafter collectively called wunens, act redundantly in primordial germ cells. We find that wunens mediate germ cell-germ cell repulsion and that this repulsion is necessary for germ cell dispersal and proper transepithelial migration at the onset of migration and for the equal sorting of the germ cells between the two embryonic gonads during their migration. We propose that this dispersal function optimizes adult fecundity by assuring maximal germ cell occupancy of both gonads. Furthermore, we find that the requirement for wunens in germ cell survival can be eliminated by blocking germ cell migration. We suggest that this essential function of Wunen is needed to maintain cell integrity in actively migrating germ cells.
在果蝇中，生殖细胞的存活和迁移方向由两种脂磷酸磷酸酶（LPP），wunen（wun）和 wunen-2（wun2）控制。wun wun2 双突变体分析表明，这两个基因，以下统称 wunens，在原始生殖细胞中具有冗余作用。我们发现 wunens 介导生殖细胞-生殖细胞排斥，这种排斥对于生殖细胞的分散以及在迁移开始时的跨上皮迁移和在它们迁移过程中两个胚胎性腺之间的生殖细胞的均等分选是必要的。我们提出，这种分散功能通过确保两个性腺中最大程度的生殖细胞占据来优化成年生殖力。此外，我们发现通过阻止生殖细胞迁移可以消除 wunens 在生殖细胞存活中的需求。我们认为，Wunen 的这个必需功能是维持活跃迁移的生殖细胞细胞完整性所必需的。
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