黑腹果蝇生殖系的起源与建立

Origin and establishment of the germline in Drosophila melanogaster.

作者信息

Chen Ruoyu, Grill Sherilyn, Lin Benjamin, Saiduddin Mariyah, Lehmann Ruth

机构信息

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Vilcek Institute of Graduate Studies, Department of Cell Biology, NYU School of Medicine, New York University, New York, NY 10016, USA.

出版信息

Genetics. 2025 Apr 17;229(4). doi: 10.1093/genetics/iyae217.

DOI:10.1093/genetics/iyae217

PMID:40180587

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12005264/

Abstract

The continuity of a species depends on germ cells. Germ cells are different from all the other cell types of the body (somatic cells) as they are solely destined to develop into gametes (sperm or egg) to create the next generation. In this review, we will touch on 4 areas of embryonic germ cell development in Drosophila melanogaster: the assembly and function of germplasm, which houses the determinants for germ cell specification and fate and the mitochondria of the next generation; the process of pole cell formation, which will give rise to primordial germ cells (PGCs); the specification of pole cells toward the PGC fate; and finally, the migration of PGCs to the somatic gonadal precursors, where they, together with somatic gonadal precursors, form the embryonic testis and ovary.

摘要

一个物种的延续依赖于生殖细胞。生殖细胞不同于身体的所有其他细胞类型（体细胞），因为它们唯一的使命是发育成配子（精子或卵子）以创造下一代。在这篇综述中，我们将探讨黑腹果蝇胚胎生殖细胞发育的4个领域：种质的组装和功能，种质包含生殖细胞特化和命运的决定因素以及下一代的线粒体；极细胞形成的过程，极细胞将产生原始生殖细胞（PGC）；极细胞向PGC命运的特化；最后，PGC迁移到体细胞性腺前体，在那里它们与体细胞性腺前体一起形成胚胎睾丸和卵巢。