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7 特斯拉下使用部分并行成像 16 倍加速的多通道多层 GE-EPI,及其在高空间和时间分辨率全脑 fMRI 的应用。

Multiband multislice GE-EPI at 7 tesla, with 16-fold acceleration using partial parallel imaging with application to high spatial and temporal whole-brain fMRI.

机构信息

Department of Radiology, School of Medicine, University of Minnesota, Center for Magnetic Resonance Research, Minneapolis, Minnesota 55455, USA.

出版信息

Magn Reson Med. 2010 May;63(5):1144-53. doi: 10.1002/mrm.22361.


DOI:10.1002/mrm.22361
PMID:20432285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2906244/
Abstract

Parallel imaging in the form of multiband radiofrequency excitation, together with reduced k-space coverage in the phase-encode direction, was applied to human gradient echo functional MRI at 7 T for increased volumetric coverage and concurrent high spatial and temporal resolution. Echo planar imaging with simultaneous acquisition of four coronal slices separated by 44mm and simultaneous 4-fold phase-encoding undersampling, resulting in 16-fold acceleration and up to 16-fold maximal aliasing, was investigated. Task/stimulus-induced signal changes and temporal signal behavior under basal conditions were comparable for multiband and standard single-band excitation and longer pulse repetition times. Robust, whole-brain functional mapping at 7 T, with 2 x 2 x 2mm(3) (pulse repetition time 1.25 sec) and 1 x 1 x 2mm(3) (pulse repetition time 1.5 sec) resolutions, covering fields of view of 256 x 256 x 176 mm(3) and 192 x 172 x 176 mm(3), respectively, was demonstrated with current gradient performance.

摘要

在 7T 人体梯度回波功能磁共振成像中应用多频带射频激发的并行成像,以及减少相位编码方向的 k 空间覆盖范围,可提高容积覆盖范围,并实现同时的高空间和高时间分辨率。研究了同时采集四个冠状切片,切片间隔为 44mm,同时进行 4 倍相位编码欠采样的 echo 平面成像,从而实现 16 倍加速和高达 16 倍的最大混叠。在基础条件下,多频带和标准单频带激发以及更长的脉冲重复时间下,任务/刺激诱导的信号变化和时间信号行为具有可比性。在当前梯度性能下,可实现覆盖视野为 256 x 256 x 176 mm(3) 和 192 x 172 x 176 mm(3) 的全脑功能映射,分辨率分别为 2 x 2 x 2mm(3)(脉冲重复时间为 1.25 秒)和 1 x 1 x 2mm(3)(脉冲重复时间为 1.5 秒)。

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