Xue Fei, Yin Shou-yu
College of Pharmacy, Yanbian University, Yanji 133000, China.
Zhong Yao Cai. 2009 Dec;32(12):1898-902.
To study the optimum inclusion process conditions for the beta-cyclodextrin complex of volatile oil from Ledum palustre.
The utilization ratio of the volatile oil from Ledum palustre was set as the index, and four factors were selected including the ratio of the volatile oil to beta-cyclodextrin, the temperature of preparation, the inclusion time and the ratio of beta-cyclodextrin to water. The optimum conditions were investigated by the orthogonal test form L9 (3(4)). The inclusion compound was identified by the ways of Micro-imaging, Thin-layer chromatography (TLC), Ultraviolet Spectroscopy (UV)and Infrared Spectroscopy (IR).
The optimum preparation conditions were as follows: volatile oils: beta-cyclodextrin was 1:8, the inclusion temperature and time was 50 degrees C and 30 min, respectively. Beta-cyclodextrin: water was 1:15.
The inclusion technology is stable and its quality is adjustable.
研究杜香挥发油β-环糊精包合物的最佳包合工艺条件。
以杜香挥发油利用率为指标，选取挥发油与β-环糊精的比例、制备温度、包合时间、β-环糊精与水的比例4个因素，采用L9(3⁴)正交试验表考察最佳条件。通过微观成像、薄层色谱法(TLC)、紫外光谱法(UV)和红外光谱法(IR)对包合物进行鉴定。
最佳制备条件为：挥发油与β-环糊精比例为1:8，包合温度50℃，包合时间30min，β-环糊精与水比例为1:15。
该包合技术稳定，质量可控。
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