Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Baystate Medical Center, Western Campus of Tufts University School of Medicine, Springfield, Massachusetts 01199, USA.
Fertil Steril. 2011 Feb;95(2):474-9. doi: 10.1016/j.fertnstert.2010.03.023.
To determine the clinical relevance of obtaining antral follicle counts (AFC) before ovarian stimulation in an IVF program.
Retrospective cohort study.
An IVF program in a large academic teaching hospital.
PATIENT(S): A total of 1,049 stimulated IVF cycles in 734 subjects between September 2003 and December 2007 selected from our program's database.
INTERVENTION(S): Basal antral follicles (AFCs) (3 mm-10 mm) were counted via ultrasound scan on cycle day 3 in luteal leuprolide acetate stimulations, or after at least 2 weeks of oral contraceptives in microdose leuprolide acetate stimulations. Patients were grouped according to basal AFC, and outcome parameters compared for AFC groups within each stimulation protocol.
MAIN OUTCOME MEASURE(S): Oocytes retrieved, ovarian response, implantation rate, cancellations, pregnancy, pregnancy loss, and live births per cycle start.
RESULT(S): Antral follicle count grouping is predictive of threefold change in ovarian response to gonadotropins and oocytes retrieved. Low AFC did predict a higher cancellation rate. Antral follicle count did not predict implantation rate, pregnancy rate, or live birth rate per cycle start.
CONCLUSION(S): Antral follicle count may be helpful in determining stimulation protocol, as it is the most reliable determinant of oocytes retrieved per starting FSH dose. Antral follicle count predicts ovarian response, not embryo quality or pregnancy.
确定在体外受精（IVF）计划中进行卵巢刺激前获取窦卵泡计数（AFC）的临床相关性。
回顾性队列研究。
大型学术教学医院的 IVF 计划。
2003 年 9 月至 2007 年 12 月期间，从我们的计划数据库中选择了 734 名患者的 1049 个接受刺激的 IVF 周期。
在黄体期亮丙瑞林醋酸酯刺激下，或在微剂量亮丙瑞林醋酸酯刺激后至少 2 周口服避孕药后，通过超声扫描计数基础窦卵泡（AFC）（3mm-10mm）。根据基础 AFC 将患者分组，并比较每个刺激方案中 AFC 组的结局参数。
获卵数、卵巢反应、着床率、取消率、妊娠、妊娠丢失和每个周期开始的活产数。
窦卵泡计数分组可预测卵巢对促性腺激素和获卵数的反应增加三倍。低 AFC 确实预测取消率更高。AFC 不预测着床率、妊娠率或每个周期开始的活产率。
AFC 可能有助于确定刺激方案，因为它是每个起始 FSH 剂量获得的卵子数量最可靠的决定因素。AFC 预测卵巢反应，而不是胚胎质量或妊娠。
