Tozman E C
University of Miami School of Medicine, Florida.
Curr Opin Rheumatol. 1991 Feb;3(1):155-9.
Sarcoidosis is an idiopathic granulomatous disease involving one or more multiple organ systems, characterized by the histologic finding of noncaseating epithelioid cell granulomas. The disease has a predilection for intrathoracic structures; the musculoskeletal system is less frequently involved. Most osseous lesions in sarcoidosis are visible in the small joints of the hands and feet. Articular disease may present as an acute or chronic polyarthritis. Muscle involvement in sarcoidosis is generally asymptomatic. Neurologic findings of the central and peripheral nervous systems may occur in sarcoidosis. Subcutaneous nodules are of diagnostic value. Sarcoid vasculitis may involve small and large blood vessels. Sarcoidosis of the exocrine glands may mimic Sjögren's syndrome. Spontaneous remission of disease often occurs. Treatment with nonsteroidal anti-inflammatory agents, corticosteroids, antimalarials, radiation therapy, and immune-modulating drugs may be beneficial in the treatment of sarcoidosis.
结节病是一种特发性肉芽肿性疾病，累及一个或多个多器官系统，其组织学特征为非干酪样上皮样细胞肉芽肿。该疾病好发于胸内结构；肌肉骨骼系统较少受累。结节病的大多数骨病变见于手足小关节。关节疾病可表现为急性或慢性多关节炎。结节病的肌肉受累通常无症状。中枢和周围神经系统的神经学表现可出现在结节病中。皮下结节具有诊断价值。结节性血管炎可累及小血管和大血管。外分泌腺结节病可能类似干燥综合征。疾病常可自发缓解。使用非甾体抗炎药、皮质类固醇、抗疟药、放射治疗和免疫调节药物进行治疗可能对结节病的治疗有益。
