引导内体成熟。
Guiding endosomal maturation.
机构信息
Department of Biology/Chemistry, University of Osnabrück, Barbarastrasse 13, Osnabrück 49076, Germany.
出版信息
Cell. 2010 Apr 30;141(3):404-6. doi: 10.1016/j.cell.2010.04.013.
PMID:20434982
Abstract
In the endocytic pathway, early endosomes are converted into late endosomes by exchange of their associated Rab GTPases. In this issue, Poteryaev et al. (2010) identify the SAND-1/Mon1 protein as a switch that shuts off the recruitment of one Rab (Rab5) and facilitates the activation of the next (Rab7).
摘要
在胞吞作用途径中，早期内涵体通过其相关 Rab GTPases 的交换转化为晚期内涵体。在本期中，Poteryaev 等人（2010）确定 SAND-1/Mon1 蛋白作为一个开关，它关闭了一个 Rab（Rab5）的募集，并促进了下一个（Rab7）的激活。
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