类视黄醇治疗视网膜疾病。
Retinoids for treatment of retinal diseases.
机构信息
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4965, USA.
出版信息
Trends Pharmacol Sci. 2010 Jun;31(6):284-95. doi: 10.1016/j.tips.2010.03.001.
Abstract
Knowledge about retinal photoreceptor signal transduction and the visual cycle required for normal eyesight has increased exponentially over the past decade. Substantial progress in human genetics has facilitated the identification of candidate genes and complex networks underlying inherited retinal diseases. Natural mutations in animal models that mimic human diseases have been characterized and advanced genetic manipulation can now be used to generate small mammalian models of human retinal diseases. Pharmacological repair of defective visual processes in animal models not only validates their involvement in vision, but also provides great promise for the development of improved therapies for millions who are progressing towards blindness or are almost completely robbed of their eyesight.
摘要
过去十年中，人们对视网膜光感受器信号转导和视觉循环的认识呈指数级增长，这些知识对于正常视力至关重要。人类遗传学的重大进展促进了候选基因的鉴定和遗传性视网膜疾病的复杂网络。以模拟人类疾病的动物模型中的自然突变已经得到了描述，并且现在可以先进的遗传操作来生成人类视网膜疾病的小型哺乳动物模型。在动物模型中对有缺陷的视觉过程进行药物修复不仅验证了它们在视觉中的作用，而且为开发针对数百万正在失明或几乎完全失明的人的改进疗法提供了巨大的希望。
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本文引用的文献
1
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Methods Mol Biol. 2010;652:247-61. doi: 10.1007/978-1-60327-325-1_14.
2
The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision.视黄醇化学中转式到顺式异构化的生化和结构基础。
Trends Biochem Sci. 2010 Jul;35(7):400-10. doi: 10.1016/j.tibs.2010.01.005. Epub 2010 Feb 24.
3
NinaB is essential for Drosophila vision but induces retinal degeneration in opsin-deficient photoreceptors.NinaB 对于果蝇的视觉至关重要，但在视蛋白缺失的感光细胞中会诱导视网膜变性。
J Biol Chem. 2010 Jan 15;285(3):2130-9. doi: 10.1074/jbc.M109.056101. Epub 2009 Nov 4.
4
Phototransduction motifs and variations.光转导基序与变异
Cell. 2009 Oct 16;139(2):246-64. doi: 10.1016/j.cell.2009.09.029.
5
Lateral diffusion of rhodopsin in photoreceptor membrane: a reappraisal.视紫红质在光感受器膜中的侧向扩散：重新评估。
Mol Vis. 2009 Aug 28;15:1717-29.
6
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Vision Res. 2009 Nov;49(22):2636-52. doi: 10.1016/j.visres.2009.04.008. Epub 2009 Apr 16.
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Hum Mol Genet. 2009 Jun 15;18(12):2277-87. doi: 10.1093/hmg/ddp163. Epub 2009 Apr 1.
8
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