Scalzone M, Coccia P, Cerchiara G, Maurizi P, Mastrangelo S, Ruggiero A, Riccardi R
Division of Pediatric Oncology, Catholic University, Rome, Italy.
J Chemother. 2010 Apr;22(2):83-7. doi: 10.1179/joc.2010.22.2.83.
Errors involving patients receiving intrathecal chemotherapy are a significant problem in oncology. Despite the improvement in the management of antineoplastic agents, unintentional intrathecal administration of chemotherapic drugs that are indicated only for systemic administration or intrathecal overdose of drugs regularly used for intrathecal chemotherapy, continue to occur. These events can result in severe neurotoxicity, usually fatal in outcome. We review reported cases of medication errors in intrathecal administration of chemotherapy described in the literature. Diverse rescue therapies have been proposed but the most effective means of managing these errors remains prevention.
涉及接受鞘内化疗患者的用药错误是肿瘤学中的一个重大问题。尽管抗肿瘤药物管理有所改善，但仍不断发生将仅适用于全身给药的化疗药物意外鞘内给药或鞘内化疗常用药物鞘内过量给药的情况。这些事件可导致严重的神经毒性，通常结局致命。我们回顾了文献中报道的鞘内化疗用药错误病例。已经提出了多种补救疗法，但管理这些错误的最有效方法仍是预防。
