Trinkle R, Wu J K
Department of Pharmacy, B.C.'s Children's Hospital, Vancouver, British Columbia, Canada.
Med Pediatr Oncol. 1996 May;26(5):344-51. doi: 10.1002/(SICI)1096-911X(199605)26:5<344::AID-MPO7>3.0.CO;2-I.
A review of mishaps involving pediatric patients receiving anticancer chemotherapy was undertaken in order to assist intervention. Although the case literature is too sparse to provide definite recommendations, suggestions for management are made in the event of an error with a high risk (based on the case literature) of life-threatening toxicities. It is recommended that all incidents be reported in the literature in order to provide a basis for devising standard treatment protocols. It is also suggested that studies using animal models continue to be done in order to provide more experimental data about toxicities and potentially beneficial rescue therapies.
为了协助进行干预,对涉及接受抗癌化疗的儿科患者的医疗事故进行了综述。尽管病例文献过于稀少,无法提供明确的建议,但对于发生具有(基于病例文献)危及生命毒性高风险的错误时的处理提出了建议。建议在文献中报告所有事件,以便为制定标准治疗方案提供依据。还建议继续开展使用动物模型的研究,以便提供更多关于毒性和潜在有益救援疗法的实验数据。