Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (MC), 24 Parvaneh, Yaman Street, Velenjak, PO Box 19395-4763, Tehran 1985717413, Iran.
Hum Reprod. 2010 Jul;25(7):1775-81. doi: 10.1093/humrep/deq088. Epub 2010 Apr 30.
Anti-Mullerian hormone (AMH) is increased in women with polycystic ovary syndrome (PCOS), suggesting a delay in ovarian aging. We examined AMH levels in PCOS and normo-ovulatory women in a population-based cohort over a period of 10 years and used this information to estimate their menopausal age.
Of a subset of 1002 non-menopausal women randomly selected from the Tehran Lipid and Glucose Study, 85 cases of PCOS were diagnosed. We frequency-matched our control subjects with PCOS cases based on age and BMI. AMH levels were assessed at the time of recruitment (T1) and twice after that (T2 and T3). AMH levels were then plotted against age of the individual at the time of the measurement and the most appropriate model was selected. Menopause was calculated based on AMH levels below 0.2 ng/ml.
AMH levels were significantly higher in PCOS cases compared with controls at the beginning of the study (5.58 +/- 3.64 versus 4.35 +/- 2.90 ng/ml, P = 0.03), but the difference diminished considerably in subsequent assessments. The rate of AMH decline in PCOS cases decreased in the second compared with the first interval; however, no apparent change in the rate of decline was observed in controls. Estimated ages at menopause were 51 [95% confidence interval (CI), 34-81] and 49 (95% CI, 38-63) years in PCOS cases and controls, respectively.
The reproductive lifespan of PCOS women extends on average 2 years beyond that of normo-ovulatory women.
抗苗勒氏管激素（AMH）在多囊卵巢综合征（PCOS）妇女中增加，表明卵巢衰老延迟。我们在一个基于人群的队列中，在 10 年内检查了 PCOS 和正常排卵妇女的 AMH 水平，并利用这些信息估计她们的绝经年龄。
从德黑兰血脂和血糖研究中随机选择的 1002 名非绝经妇女中选取了 85 例 PCOS 病例。我们根据年龄和 BMI 与 PCOS 病例进行了频数匹配对照。在招募时（T1）和之后两次（T2 和 T3）评估 AMH 水平。然后将 AMH 水平与个体测量时的年龄进行绘图，并选择最合适的模型。绝经是根据 AMH 水平低于 0.2ng/ml 来计算的。
在研究开始时，PCOS 病例的 AMH 水平明显高于对照组（5.58±3.64 与 4.35±2.90ng/ml，P=0.03），但在随后的评估中差异大大缩小。与第一间隔相比，PCOS 病例的 AMH 下降率在第二间隔下降；然而，在对照组中没有观察到下降率的明显变化。PCOS 病例和对照组的绝经年龄估计分别为 51 岁（95%置信区间，34-81 岁）和 49 岁（95%置信区间，38-63 岁）。
PCOS 妇女的生殖寿命平均比正常排卵妇女延长 2 年。
