Parahuleva N, Pehlivanov B, Dimitrakova E, Malinova M, Mladenova M
Akush Ginekol (Sofiia). 2012;51(6):22-6.
Anti-Mullerian hormone (AMH) is a glycoprotein produced by the granulosa ovarian cells with respect to the regulation of the follicular growth and development. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disturbances affecting 6-7 of women in reproductive age. Women with PCOS exhibit a number of metabolic and endocrine disturbances some of which are paramount in the pathogenesis of PCOS. The studies examining the connection between AMH and PCOS are few and quite controversial. Women with PCOS are considered to have significantly lower levels of AMH as compared with controls which is interpreted as resulting from the greater number of pre-antral follicles, or a result of the specific synthesis of AMH by granulose cells causing follicular arrest in PCOS.
抗苗勒管激素（AMH）是一种由卵巢颗粒细胞产生的糖蛋白，用于调节卵泡的生长和发育。多囊卵巢综合征（PCOS）是最常见的内分泌紊乱疾病之一，影响6%至7%的育龄女性。患有PCOS的女性表现出多种代谢和内分泌紊乱，其中一些在PCOS的发病机制中至关重要。研究AMH与PCOS之间联系的研究较少且颇具争议。与对照组相比，患有PCOS的女性被认为AMH水平显著降低，这被解释为是由于窦前卵泡数量较多，或者是PCOS中颗粒细胞特异性合成AMH导致卵泡停滞的结果。
