Holoch Kristin J, Lessey Bruce A
Department of Obstetrics and Gynecology, Greenville Hospital System, Greenville, South Carolina 29605, USA.
Clin Obstet Gynecol. 2010 Jun;53(2):429-38. doi: 10.1097/GRF.0b013e3181db7d71.
Endometriosis is an enigmatic disease affecting up to 10% of reproductive-aged women causing pain and infertility. Up to 50% of women with endometriosis are infertile, and agreement about treatment options has been difficult to establish. The association between endometriosis and infertility is derived from comparisons of fertile and infertile women, animal models, donor sperm studies, and in vitro fertilization results. Diagnostic approaches based on endometrial changes associated with endometriosis are also providing insights into possible mechanisms of infertility, especially in women with milder forms of the disease. Treatment of endometriosis, including surgical ablation or resection, is cost-effective and offers the potential for improvement in cycle fecundity. Medical management of endometriosis-associated infertility has not been proven outside of in vitro fertilization.
子宫内膜异位症是一种神秘的疾病，影响着高达10%的育龄妇女，会导致疼痛和不孕。高达50%的子宫内膜异位症女性不孕，且很难就治疗方案达成共识。子宫内膜异位症与不孕之间的关联源自对有生育能力和不孕女性的比较、动物模型、供体精子研究以及体外受精结果。基于与子宫内膜异位症相关的子宫内膜变化的诊断方法也为不孕的可能机制提供了见解，尤其是在病情较轻的女性中。子宫内膜异位症的治疗，包括手术消融或切除，具有成本效益，并有可能提高周期受孕率。除体外受精外，子宫内膜异位症相关性不孕的药物治疗尚未得到证实。
